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This dual-phase clearance profile requires precise washout period planning for sequential dosing protocols

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doi:10.1016/j.bbr.2019.112359 84

Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema

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