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That breadth matters because phase 3 trials test efficacy and safety in larger, more representative populations than phase 2 and weight-loss figures often moderate as populations widen

Melcher AH

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C.Cadar AndoneB.CrinteaA.TatuC.et al (2024)

By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

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