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Methylation of the CpG islands in the NRF2 gene promoter typically suppresses NRF2 transcriptional activity, leading to reduced expression levels and impacting the cells antioxidant functions [148]

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Abstract Corticotropin-releasing factor (CRF) is the hallmark brain peptide triggering the response to stress and mediatesin addition to the stimulation of the hypothalamus-pituitary-adrenal (HPA) axisother hormonal, behavioral, autonomic and visceral components