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Examining hepatic GH receptor signalling, IGF-1 and IGFBP-3 production kinetics, tissue-level IGF-1 receptor signalling in muscle, bone, and adipose tissue, and downstream anabolic and metabolic biology and in the clean research context of selective GH stimulation uncontaminated by prolactin co-elevation
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However, further investigation is needed to understand how these DEGs and pathways translate into the broader systemic effects that become evident following the engagement of CNS GIPR and GLP-1R
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