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By reducing the number of LDL receptors (LDLR) on the surface of liver cells, PCSK9 leads to the accumulation of LDL-C, increasing the risk of CVDs

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Golgi staining of aged astrocytes did not show major morphological changes 529 , whereas age-dependent changes in astrocytes stained with antibodies against S100B and glutamine synthetase are characterised by complex region-dependent changes ranging from atrophy to hypertrophy

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