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1 Diabetology Unit, ASL Roma 4, Civitavecchia, Italy, 2 Unicamillus University, Roma, Italy, 3 ASL Roma 1, Roma, Italy, 4 District 63, Outpatient Clinic of Diabetologia, Asl Salerno, Salerno, Italy

In adjusted analyses, semaglutide reduced epigenetic aging across multiple second- and third-generation clocks, including PhenoAge ( 4.9 years/year, p = 0.004), PCGrimAge ( 3.1, p = 0.007), GrimAge V2 ( 2.3, p = 0.009), OMICmAge ( 2.2, p = 0.009), RetroAge ( 2.2, p = 0.030), and DunedinPACE ( 0.09 units, 9% slower, p = 0.01)

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En cuanto a la suplementacin, se recomienda el Glutatin en forma liposomal , encapsulado en fosfolpidos que preservan mejor su estructura y aseguran su biodisponibilidad.

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In addition, the novel observation that GHK might target an epigenetic pathway further enhances its potential as an anti-aging peptide [32]