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In the SURPASS-2 head-to-head trial, tirzepatide produced nearly double the weight loss of semaglutide (15% vs 8% in T2D patients)

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doi: 10.1038/srep27740 50 GaluppoM.IoriR.De NicolaG

Metformin is not suitable for individuals with certain medical conditions, including significant kidney impairment or specific metabolic disorders