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JHU083 has also demonstrated excellent therapeutic efficacy in preclinical models of IDH-mutant gliomas and significantly reduces mTOR signaling (Yamashita et al., 2021)

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Various pharmaceuticals, including erastin and RSL3, provoke ferroptosis by diminishing glutathione peroxidase 4 (GPX4) activity, facilitating the accumulation of lipid peroxides [88]

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