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Studies have shown benefits in both hypothyroidism and hyperthyroidism

DPP-4 inhibitors lack significant clinical benefits over newer anti-diabetic agents (i.e., GLP-1 agonists and SGLT2 inhibitors)

While each compound produces meaningful results independently, their combined action addresses multiple metabolic pathways simultaneously, creating results that exceed what either compound achieves alone

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If liver and renal function were normal and CBCs were not below the normal range, then the child was eligible to participate in Phase 1