setmelanotide vs tirzepatide New Developments in Pharmacological Treatment of Obesity and Type 2 Diabetes—Beyond and within GLP-1 Receptor Agonists Current Strategies in Managing Obesity

When to involve your clinician Before withdrawal

Nonetheless, even a minor adverse event might cause inconvenience and non-adherence or drug discontinuation

Your appetite is down, the scale is moving in the right direction, and then boom

GLP-1 receptor agonists slow gastric emptying as part of their therapeutic effect

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Common side effects include: Nausea Vomiting Diarrhea Stomach pain Constipation Weight loss Serious but less common side effects include: Severe allergic reactions Increased risk of thyroid tumors (including medullary thyroid carcinoma, MTC) Risk of multiple endocrine neoplasia syndrome type 2 (MEN 2) Pancreatitis Diabetic retinopathy complications Hypoglycemia, especially with other diabetes medications Worsening kidney disease Gallbladder disease and gallstones This is not a full list of side effects