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Mathiesen DS, Lund A, Holst JJ, Knop FK, Lutz TA, Bagger JI

Prof Adam Taylor, from Lancaster University, said potential benefits in pre-clinical studies such as those in animals and cells do not necessarily mean a peptide is beneficial for humans

used optogenetics to study excitatory projection neurons and inhibitory PV neurons of the mPFC and subsequently found that an increase in the cellular E/I ratio leads to severe impairments in information processing and behaviour

Abbreviations MDS: Myelodysplastic syndromes SCD: Sickle cell disease IOC: Iron overload cardiomyopathy NTBI: Non-transferrin-bound iron LPI: Labile plasma iron DMT1: Divalent metal transporter 1 ZIP14: ZRT/IRT-like protein 14 LCN-2: Lipocalin-2 TTCC: T-type calcium channels LTCC: L-type calcium channels LCI: Labile cellular iron LIP: Labile iron pool FeS clusters: Iron-sulfur clusters DFP: Deferiprone ETC: Electron transport chain IMM: Inner mitochondrial membrane OXPHOS: Oxidative phosphorylation ROS: Reactive oxygen species Mfrn: Mitoferrin MCU: Mitochondrial calcium uniporter RIRR: ROS-induced ROS release mPTP: Mitochondrial permeability transition pore m: Mitochondrial membrane potential mtDNA: Mitochondrial DNA BCL-2: B-cell lymphoma-2 SS: Szeto-Schiller PCD: Programmed cell death BMMSCs: Bone marrow mesenchymal stromal cells MAPK: Mitogen-activated protein kinase MOMP: Mitochondrial outer membrane permeabilization DAMPs: Damage-associated molecular patterns OPA1: Optic atrophy 1 Drp1: Dynamin related protein 1 Fis1: Fission 1 RET: Reverse electron transport CoQ: Coenzyme Q10 TPP+: Triphenylphosphonium PGC-1: Peroxisome proliferator-activated receptor-gamma coactivator-1alpha KD: Ketogenic diet PPAR: Peroxisome proliferators-activated receptor SIRT: Sirutin References PONKA P

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Glutathione, a master antioxidant, emerges as a key player in skin health, renowned for its ability to enhance skin glow and vitality