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Tsuji-Naito et al27 demonstrated that DHLHZn (sodium zinc dihydrolipoyl histidinate, compound of Zn2+/dyhydrolipoic acid derivative complex, which was developed for cosmetic/medical use) serves as a potentially effective skin-lightening agent, an effectiveness that is based on the compounds covalent scavenging of DOPAquinone, resulting in depigmentation.27 Our study revealed that some mild adverse events occurred in the first four weeks, although this occurrence was not statistically significant

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Minoxidil remains strictly a hair treatment with no broader applications

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Discontinue use if severe adverse reactions occur [14]

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