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IL27pepL, also known as 27pepL, is a novel derivative of the cytokine IL-27

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The major energy contributor residues of the hormonereceptor complex were identified as residues in the receptor hydrophobic patch, where tryptophan 104 and tryptophan 169 contributed significantly to site 1 interactions

This conjugate binds covalently to cysteine-34 on circulating serum albumin (the same site exploited by fatty-acid-albumin binders like insulin detemir)

The reason is that the carbonsulfur lyase (CSL) enzymes originating from yeast (Irc7 and Str3 are the most well studied) have low activity toward 3MH precursor