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Material and Methods For this narrative review, we searched for articles published in PubMed and Google Scholar between January 1, 1990 and March 2022 using the keywords oral, systemic treatment, treatment, therapy, skin aging, photoaging, oral collagen, isotretinoin, tranexamic acid, Polypodium leucotomos, niacinamide, antioxidants, metformin, hormonal replacement therapy, melatonin, flavonoids, vitamin, vitamin C, vitamin E, vitamin D, senolytics, hyaluronan, hyaluronic acid, glucosamine, coenzyme Q10, glutathione, marine complex, pine bark extract, food supplements, aloe vera, and Hydrangea serrata

Age and Skin Elasticity : Younger individuals or those with good skin elasticity are less prone to sagging