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(71) observed that Ex-4 can restrain neuroinflammation and stabilize the BBB via PI3K/Akt-mediated suppression of glycogen synthase kinase-3 (GSK-3) in the brain after warfarin-associated HT post-cerebral ischemia of mice

Progr Neurobiol

Notably, a negative correlation was observed between free T3 levels and the percentages of total TGR5-agonistic BAs (Supplementary Fig

Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP-2 and MMP-9 via h19/mir-29b-3p and akt/mtor/autophagy signaling pathways

doi:10.1016/j.dld.2012.11.002

These drugs work by acting on different hormones that help regulate weight, insulin levels and craving centers in the brain