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doi: 10.1016/j.cbpb.2022.110811 93 JinWWangH-DHuZYanWChenGYinH-X

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Haddaji et al

Second, it is able to induce the combination of ,-unsaturated ketones and GSH through the nucleophilic addition reaction, depleting GSH and reducing the amount of GSH available to combine with chemotherapeutic agents, thus producing an overall GST-inhibitory effect by sensitizing a cell to chemotherapeutic agents

Furthermore, GPX4 coenzyme GSH works to convert phospholipid peroxides to phospholipids, thereby shielding cells from ferroptosis [45]

NMNAT: Its an NAD(+) synthase Its a chaperone Its a neuroprotector