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As the applications of Pycnogenol are so diverse, the studies are sorted by health domain and by date of publication

Refrigeration helps it last longer and stay effective, but some brands stay stable at room temperature

= Link to open-access journal article

As a result of the numerous benefits that have been discovered, 7nAChR is regarded as a potentially beneficial therapeutic target in CNS disorders, including neurodegenerative diseases like Alzheimers disease (AD) and Parkinsons disease, psychiatric disorders like autism and schizophrenia, and cerebrovascular diseases like ischemic stroke, and hemorrhage stroke [29,30,31,32]