For patients with diabetes or prediabetes, semaglutide provides greater metabolic benefit
The post hoc analysis of patients only from the PIONEER 6 (evaluating oral semaglutide) and SUSTAIN 6 (evaluating sc semaglutide) studies found a 23.8% reduction in MACEs associated with semaglutide treatment (HR 0.76, 95% CI 0.620.92), especially in the prevention of nonfatal stroke (HR 0.65, 95% CI 0.430.97) [62]
Discussion There are several reports on the effects of GLP-1RA on the gut microbiota in rodents 26,27,28
Food does not affect the absorption or efficacy of subcutaneous GLP-1 injections, so you may administer them at any time regardless of meals
Understanding GLP-1 Peptides What Are GLP-1 Peptides
Tirzepatide is also a once-weekly injectable, but it works on both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors