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Researchers may utilize AHK-Cu in cell culture models, dermal biology assays, follicular microenvironment studies, wound-repair pathway investigations, and broader experiments involving peptide-mediated copper transport and cellular adaptation

But it also uses riboflavin

In high doses, it can inhibit melanin production

Furthermore, high IGFBP5 expression correlated with shorter survival after CTLA-4 blockade in a melanoma cohort, suggesting that IGF-axis activation may contribute to ICB resistance across tumor types

10.1016/j.lfs.2021.119512 8 AlsharifI