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Disclosures: Benjamin Scirica reports institutional research grants to Brigham and Womens Hospital from Better Therapeutics, Merck, Novo Nordisk, and Pfizer

Analysis of the large VITATOPS study, which was a cohort of 1,400 participants expanding over 10 countries, found a significant reduction (~4 mol/L) in homocysteine in the group receiving vitamin B12, folate, and vitamin B6 supplementation compared to the control (29, 30)

This dual action targets adipose tissue directly through the beta-3 adrenergic receptor pathway

For example: Whole milk has more fat and calories than skim or low-fat milk

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Extrathyroidal extension showed positive association with GLP-1R expression that was almost significant