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Moreover, disruption of the insulin signaling cascade, particularly through reduced InsR and IRS-1 expression, is a well-known feature of diabetic encephalopathy 48

Studies have also shown that tirzepatide provides improvements in people with obstructive sleep apnea (OSA) and Zepbound was recently approved by the FDA for this indication

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GLP-1s for Rheumatoid Arthritis For people with rheumatoid arthritis (RA) who are also overweight or who have obesity, GLP-1s may offer additional benefits

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