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Hepatology 73, 795810

Upon entry into the cell through the aforementioned glutamine transporters, glutamine is enzymatically deaminated by GLS, leading to the generation of glutamate (Fig

Oxidative stress intersects with multiple age-associated mechanisms, including mitochondrial dysfunction, genomic instability, epigenetic alterations, dysregulated nutrient sensing, and chronic low-grade inflammation

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Continued approval for this indication may depend upon demonstration of further clinical benefit in studies

This is partly because the same dose of retatrutide is distributed across more body mass, producing a lower effective concentration per kilogram