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ATTAIN Phase 3 trials show a manageable GLP-1-class side effect profile No unexpected serious safety signals have emerged in published data to date Hypoglycaemia risk is low when used without insulin or sulphonylureas Long-term cardiovascular outcomes data is still being collected Regulatory review by bodies including the MHRA is ongoing as of 2026 Orforglipron Side Effects: What to Expect Understanding side effects is central to any honest safety discussion

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