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Intermuscular adipose tissue-derived inflammatory adipokines, exacerbated by aging, obesity, and sedentary behavior, promote both fat accumulation and chronic inflammation within skeletal muscle, driving adipogenic differentiation at the expense of myogenesis and thereby contributing to reduced muscle quality and increased metabolic risk [81]

[1] [2] GLP-1 is released by specialized enteroendocrine cells called L-cells that line the lower small intestine and colon