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Per the prescribing information, it is also recommended that a reduction in the dose of pre-existing insulin secretagogue medications be considered when initiating liraglutide to minimize the risk of treatment-emergent hypoglycemia

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Thats because dual agonists increase the chance of binding to either receptor in your body

Results showed a mean body weight reduction of 8.0% with liraglutide compared to 2.6% with placebo

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If you have persistent GI intolerance, certain comorbidities, or you personally value a moderate weight change over maximal loss, a clinician might target a mid-range maintenance dose