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Age-related sarcopenia begins around age 35 and accelerates during perimenopause and menopause, primarily due to declining estrogen levels

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Dosing & Reconstitution Guide Educational guide for reconstitution and nightly dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Frequency: Inject once daily subcutaneously in the evening, approximately 3060 minutes before bedtime [4]

In certain embodiments, a responder may be considered as a subject for which treatment as described herein provides for improvement in one or more VABS-II domains/sub-domains such as: communication score, receptive V-scale score, expressive v-scale score, daily living skills, or personal v-scale score