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Microbiome disruption GLP-1 medications like semaglutide slow digestion, which can alter the balance of bacteria in the gut

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The GPRC6a, closely related to the CaSR, has been cloned from human and rodent cells, and subsequently localized on the GLUTag L-cell line (139)

In line with our results, two large clinical trials, in which NAFLD was an established comorbidity among the enrolled patients, have recently shown a dose-dependent reduction of serum ALT and high-sensitivity C-reactive protein values after treatment with Semaglutide [38]