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The medication requires gradual dose titration over several months to minimize gastrointestinal side effects, which are the most common tolerability concerns

Fluctuations in certain hormones can cause melasma, which is why it commonly occurs during pregnancy

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High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine

Blood tests can identify deficiencies early, allowing for timely intervention