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doi: 10.1038/nrendo.2018.24 141 MoranLTeedeH

This triple-agonist mechanism of action distinguishes it from currently available treatments such as Wegovy (which targets one receptor) and Mounjaro (which targets two)

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To compare outcomes, each mom-to-be was matched with three pregnancies from mothers who had never used the drugs

In late-stage trials, people taking orforglipron lost an average of about 12% of their body weight over roughly 72 weeks , and head-to-head studies suggest it may outperform standard oral semaglutide tablets (Rybelsus) in both weight loss and blood sugar control

Treatment with anticoagulation is highly effective when started promptly