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Even more frequently, non-specific resistance mechanisms, involving modification of cell envelope charge, composition or rigidity as well as increased expression of drug resistance transporters can contribute to resistance
And I think it opens up a whole new avenue of clinical research as well, because there is a lot going on in the antiobesity space with drug development and I think the future is very bright in terms of testing those agents, not just for weight loss but also for really significant benefits in patients with heart failure
Phase 2 Obesity Trial New England Journal of Medicine (2023) The pivotal Phase 2 obesity trial of retatrutide, published in the New England Journal of Medicine, enrolled 338 adults with obesity (BMI 30) or overweight with weight-related comorbidities
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