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10.1172/JCI26640

The severity of colon mucosal damage was evaluated using the colonic mucosal damage index (CMDI) following the criteria outlined by 2.6 H&E and AB-PAS staining Paraffin-embedded colonic tissue blocks were cut into 4-m-thick sections for H&E staining (Table 2

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Given that NOX and NOS activity in neutrophils and macrophages depend upon G6PD-derived NADPH and reduced glutathione (GSH) (7), the role of G6PD and the PPP has been studied in these cell types, and roles for G6PD activity have been identified even beyond the oxidative burst