Convenience / Administration: Convenience / Administration: Oral therapies offer some promise as a more convenient option than the leading injectables
Patent US2477812
William Seeds explains what is happening in his book Peptide Protocols Volume 1: [AOD-9604] is unable to induce dimerization and thereby activation of the receptor (no competition with HGH) This fragment holds the fat-reducing and tissue repair sequence and mimics the effect of HGH on lipid metabolism, without having growth-promoting or pro-diabetic effects [AOD-9604] inhibits lipoprotein lipase activity in adipose tissue, stimulating lipolysis in adipocytes Since AOD-9604 does not interact with growth hormone receptors, it means the peptide has the following advantages over HGH: Does not increase IGF-1 production Does not induce insulin resistance Does not stimulate muscle growth Since beta-3-adrenergic receptor activation appears to be a secondary mechanism of the AOD-9604 peptide, its primary and complete mechanism for fat mobilization and/or fat cell death within adipose tissue is not currently known
But the doses required (typically 5001,500 mg of berberine per day) are far beyond what a small patch can plausibly deliver through the skin, even before you account for the absorption barrier
Choose 2 mL (5 mg/mL) or 3 mL (3.33 mg/mL) to keep injection volumes small
Supplementation with vitamin D3 at 2000 to 5000 IU per day is commonly recommended during healing, though individual needs vary based on baseline levels, sun exposure, and body composition
