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Studies show that stopping GLP-1 drugs without structured guidance increases the risk of rapid weight regain, with some patients regaining 50% of lost weight within months of discontinuation

Bile acid sequestrants (BASs) are anion exchange resins that prevent ileal uptake of bile acids by trapping BAs in the intestinal lumen, resulting in induced de novo synthesis of bile acids from cholesterol in the liver, which decreases plasma cholesterol

doi: 10.1212/01.wnl.0000140291.86406.d1 65 WilletteAAXuGJohnsonSCBirdsillACJonaitisEMSagerMAet al

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Dose titration and its impact Most GLP-1 protocols involve gradual dose increases during months two and three