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Keywords: Weight Loss, Lipid Metabolism, Ketone Bodies, Caloric Restriction, Body Composition Introduction Calorie restriction (CR), a reduction in caloric intake without malnutrition, has consistently been found to produce reductions in body weight and extend healthy life span across a variety of species,(1) including non-human primates.(2) Studies conducted in overweight humans indicate short-term CR (6-months) can significantly improve several cardiovascular risk factors, insulin-sensitivity, and mitochondrial function.(3) Thus, there is emerging evidence from human clinical trials to indicate in overweight adults, CR may have a number of beneficial effects, in addition to weight loss

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The activity of NO as a biological messenger classifies it as a gasotransmitter

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