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Furthermore, cytoplasmic dsDNA levels are significantly increased in FLS from RA patients, causing upregulation of genes such as IL-6 , CXCL10 , TNF- , MMP-13 , IL-1 , and IL-8 via a cGAS-dependent mechanism that also disrupts joint homeostasis [22]

Long-term outcomes Do combinations provide sustained benefits beyond monotherapy over 1-2 year timeframes

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That supports the research rationale, but it still does not prove this specific pre-blended product is effective or safe in humans

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Seyfried TN, Huysentruyt LC