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Levels of ThTP and AThTP are higher in fast growing, non-differentiated cells, highlighting the significance of these thiamine derivatives in cellular differentiation (144)

In this regard, evidence has been provided that a mutated p53 form can sustain Nrf2-mediated antioxidant response to allow cancer cell adaptation to the tumour-typical increased ROS levels [35] and to confer chemoresistance [36]

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Wear PPE including gloves, lab coat, and protective eyewear Handle compounds within approved laboratory workspaces Avoid inhalation, ingestion, or direct contact Dispose of materials according to institutional chemical waste procedures Maintain proper labeling and documentation for stored research compounds These practices support safe and controlled laboratory operation