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Baseline WOMAC pain score: approximately 6 out of 20 Reduction in active treatment arms: approximately 4.5 points , representing a ~76% decrease from baseline Complete freedom from knee pain at week 68: reported by roughly 1 in 8 patients (12.5%) receiving retatrutide, compared to just 4.2% in the placebo group A 76% reduction in pain scores is extraordinary approaching the range typically seen after total knee replacement surgery

10.1038/emm.2007.66 133 JeongC

Studies in humans have shown that acetylated forms keep more of the drug in the blood for longer than non-acetylated forms

This was an event-driven trial and 122 events were planned

These models help scientists investigate how peptide-based signals influence different biological pathways in controlled experimental conditions

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