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Optimizing absorption for intranasal delivery of drugs targeting the central nervous system using alkylsaccharide permeation enhancers
Concerning the first criterion, the percentage identity between members of a given class is usually above 50%, whereas it is usually below 20% between classes
Three studies investigated the effect of liraglutide, an approved GLP-1 agonist for the treatment of obesity
Yamashita H, Takenoshita M, Sakurai M, Bruick RK, Henzel WJ, Shillinglaw W, Arnot D, Uyeda K (2001) A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
The biology is compelling enough to justify that careful engagement
IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is an 83-amino-acid synthetic variant of human IGF-1, engineered with two key structural modifications: a glutamic acid substitution for arginine at position 3 (R3) and a 13-amino-acid N-terminal extension peptide
