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At the highest doses of retatrutide tested12 milligrams (0.19 grain)participants lost 28.3 percent of their weight on average

The most significant clinical data for retatrutide to date comes from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)

How Much Weight Loss Do Clinical Trials Show: Retatrutide vs Tirzepatide Weight Management Research Data Phase 3 clinical trial data places retatrutides average body weight reduction at approximately 28% over 18 months, a figure that Eli Lilly and independent commentators have described as comparable to outcomes typically associated with bariatric surgery [2]

This is why newer GLP-1 pills are packed with much higher doses of semaglutideto help make up for what's lost during digestion

These renal benefits independently contribute to cardiovascular risk reduction, though SGLT2 inhibitors remain foundational therapy for heart failure and CKD when appropriate

Many clients were understandably curious not only about physical effects, but also about how these medications might impact mental health