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Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including semaglutide

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The structured, primary care-led intensive weight management programme involved total diet replacement (34523569 kJ/day [825853 kcal/day] for 35 months) followed by stepped food reintroduction and structured support for long-term weight loss maintenance

Consistent moderate activity like walking, swimming, or cycling provides excellent support for weight loss

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