The active metabolite, 1,25-dihydroxyvitamin D3 (calcitriol), is generated via sequential hydroxylations in the liver (by CYP2R1) and kidneys (by CYP27B1) (80)
Clinical Update 6/11/2024 Folic Acid vs Folate
When estrogen levels begin the gradual perimenopause transition in the mid-to-late 30s, GH pulse amplitude and frequency decline alongside it
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This heterogeneity results from the inter-cellular variability in abundance of the corresponding ion transport pathways [NMDA receptors, voltage-gated Ca 2+ channels (Cav2.1), and LPA receptors] in RBC of healthy humans (Makhro et al., 2013
Results are limited by genetic factors and natural phototype, meaning changes are gradual and within biological limits