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University of Colorado Anschutz Medical Campus

Empagliflozin and dapagliflozin are TGA approved for heart failure independent of ejection fraction or diabetes status and are PBS listed for heart failure with reduced ejection fraction (HFrEF, with left ventricular ejection fraction 40%)

Patients taking diabetes medications or blood pressure medications should be especially careful because weight loss and appetite changes may alter medication needs

Some versions are marketed as sublingual drops, meant to be placed under the tongue for faster absorption

Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work

Comparing GLP-1 Pills and Injectable Regimens When comparing oral GLP-1 medications with injectable options, clinicians must weigh efficacy, cardiovascular data, dosing schedules, and patient lifestyle