Glucagon-like peptide-1 (GLP-1) is a naturally occurring hormone produced primarily by specialised cells in the distal small intestine (ileum) and colon, called L-cells
The definition of injection site reactions in clinical trials typically includes pain, erythema, pruritus, and other local symptoms that patients report to investigators
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It turned out p.S539W was creating GLP-1 resistance, stopping the hormone from being properly processed by the body
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Bringue J, Guillamat-Prats R, Martinez ML, Torrents E, Camprubi-Rimblas M, Blanch L, et al