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The study successfully met its primary endpoint with the highest dose achieving 63.5% clinical response versus 27% placebo at Week 12 and 30.2% clinical remission versus 11.1% placebo, with favorable tolerability and continued improvement through Week 28, though the study completion date and final comprehensive results are pending presentation at upcoming medical congresses

10.1016/j.cyto.2014.06.019 [DOI] [PMC free article] [PubMed] [Google Scholar] Mills P

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Inhibiting LOX and ACSL4 activity may effectively prevent chondrocyte ferroptosis and decelerate OA development