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While leptin levels are not significantly altered, hyper- but not hypothyroidism is associated with normal or increased serum concentrations of adiponectin 109

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28 Beyond its primary role, GLP1 has a regulatory and protective role in the ileal brake mechanism to optimize digestion and nutrient absorption

Although neither intervention significantly altered global microbial diversity indices, the targeted modulation of specific taxa supports the feasibility of precision microbiome-based therapies for DKD

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