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To induce barrier damage cells were incubated with proinflammatory cytokines (CK) tumor necrosis factor- (TNF-) and interleukin-1 (IL1-) both at 10 ng/ml concentration

The four main families of PRRs are toll-like receptors (TLRs), nucleotide-binding oligomerization domain-like receptors (NLRs), C-type lectin receptors, and RIG-1 like receptors (Janeway and Medzhitov, 2002

It also increases collagen and VEGF production (supporting the follicle environment) and suppresses TGF-1 (blocking a key hair loss signal)

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Recovery from training is the third dimension of the synergy