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While the relationship between IGF-1 signaling and longevity is complex, with both positive and negative effects saw depending on context, research with IGF1 LR3 has helped clarify the specific effects of receptor start independent of the complex control mechanisms that govern native IGF-1

is a scientific advisory board member of SNIPR Biome, Excision Biotherapeutics, and LeapFrog Bio, consults for BiomX, and is a scientific advisory board member and co-founder of Acrigen Biosciences and ePhective Therapeutics

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doi: 10.6004/jnccn.2012.0034 3 TyrrellHPayneM