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When an adult with type 2 diabetes starts initial therapy with metformin and one or more other medicines: introduce the medicines one at a time, starting with metformin and checking tolerability if using an SGLT-2 inhibitor, start this as soon as metformin is at the maximum tolerated dose if using a GLP-1 receptor agonist or tirzepatide, start this as soon as the SGLT-2 inhibitor is at the maximum tolerated dose Reviewing metformin For adults with type 2 diabetes who are already taking standard-release metformin: continue with this treatment or switch to modified-release metformin if standard-release metformin is not tolerated or if this is the person's preference Reviewing other medicines consider continuing SGLT-2 inhibitors for their cardiovascular or renal benefits, even if they do not help the person reach their individualised glycaemic targets

Use a magnifying glass or ask about syringes with bold markings

doi: 10.1523/JNEUROSCI.1007-05.2005

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10.1002/ptr.7136

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