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Description

The SURMOUNT-1 trial evaluating tirzepatide demonstrated substantial results, with participants achieving mean weight reductions of approximately 15% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) over 72 weeks

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Reassuringly, the ERK1/2 kinase substrate motif Px[s/t]P was significantly enriched among the MEK-dependent sites as expected (Fig

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