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Under hypoxia or mitochondrial dysfunction, -KG can be converted to citrate by Isocitrate dehydrogenase (IDH 2) catalyzed carboxylation reaction, which is used for the synthesis of amino acids and fatty acids and the production of reducing agent NADPH

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Monitoring and adjusting your dose Optimal dosing often requires adjustment based on individual response

Our study not only compared GLP-1 receptor agonists with placebo groups but also with traditional antidiabetic drugs

To further support this hypothesis, the researcher has found that metabolic therapy causes alteration in gut microbiota, which may be involved in targeting potential hotspot of ASD [162]

JAMA 2009